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Fireball in Trollskull Alley
In Chapter 3: Fireball, an explosion kills nearly a dozen people in Trollskull Alley not far from the PCs’ front door. Their investigation leads them to Gralhund Villa.
WHAT HAPPENED:
Dalakhar was attempting to meet with Renaer Neverember at Trollskull Manor. 
Why?
Dalakhar (and probably also Renaer) was being tracked by the Gralhund, Zhentarim, Cassalanters, and possibly others, since they all suspect them of having valuable information or one of the eyes.
A small team of Zhentarim agents led by Urstul Floxin attempted to waylay Dalakhar as he came down Trollskull Alley.
The Gralhund nimblewright, observing the scene from a nearby rooftop, used a necklace of fireballs to launch a fireball which kills Dalakhar, and most of the Zhentarim agents including Ziraj, but not Urstul Floxin (who barely survives, but is incapacitated). The Gralhund nimblewright jumped off the roof, dashed forward, rifled through Dalakhar’s pockets, and took the Stone of Golorr. It then ran off, returning to Gralhund Villa.
MOTIVATION: The explosion breaks most of the brand-new windows on Trollskull Manor. This will be a PITA for the party, but may not be enough to incite vengeance. So the explosion also has to kill one the party's waterdeep shopkeepers friends - probably Fala, the nextdoor apothecary, who helped with herb infused cocktails and hosting community events in the alley.
The Zhentarim will also seek retribution, and Yagra will be forthcoming about this, but probably doesn't know that Davil suspects that the stone of Golorr was the target.